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Aberrant monomethylation of histone H4 lysine 20 activates the DNA damage checkpoint in Drosophila melanogaster

PR-Set7 is a histone methyltransferase that specifically monomethylates histone H4 lysine 20 (K20) and is essential for cell proliferation. Our results show that in PR-Set7 mutants, the DNA damage checkpoint is activated. This phenotype is manifested by reduction in both the mitotic and the S phase...

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Autori principali: Sakaguchi, Ayako, Steward, Ruth
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063935/
https://ncbi.nlm.nih.gov/pubmed/17227890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200607178
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