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The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death
The Apaf-1 protein is essential for cytochrome c–mediated caspase-9 activation in the intrinsic mammalian pathway of apoptosis. Although Apaf-1 is the only known mammalian homologue of the Caenorhabditis elegans CED-4 protein, the deficiency of apaf-1 in cells or in mice results in a limited cell su...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2063725/ https://ncbi.nlm.nih.gov/pubmed/16533943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200512126 |
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