A motor neuron disease–associated mutation in p150(Glued) perturbs dynactin function and induces protein aggregation

The microtubule motor cytoplasmic dynein and its activator dynactin drive vesicular transport and mitotic spindle organization. Dynactin is ubiquitously expressed in eukaryotes, but a G59S mutation in the p150(Glued) subunit of dynactin results in the specific degeneration of motor neurons. This mut...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Levy, Jennifer R., Sumner, Charlotte J., Caviston, Juliane P., Tokito, Mariko K., Ranganathan, Srikanth, Ligon, Lee A., Wallace, Karen E., LaMonte, Bernadette H., Harmison, George G., Puls, Imke, Fischbeck, Kenneth H., Holzbaur, Erika L.F.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2006
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063705/
https://ncbi.nlm.nih.gov/pubmed/16505168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200511068
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars