A motor neuron disease–associated mutation in p150(Glued) perturbs dynactin function and induces protein aggregation

The microtubule motor cytoplasmic dynein and its activator dynactin drive vesicular transport and mitotic spindle organization. Dynactin is ubiquitously expressed in eukaryotes, but a G59S mutation in the p150(Glued) subunit of dynactin results in the specific degeneration of motor neurons. This mut...

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Détails bibliographiques
Auteurs principaux: Levy, Jennifer R., Sumner, Charlotte J., Caviston, Juliane P., Tokito, Mariko K., Ranganathan, Srikanth, Ligon, Lee A., Wallace, Karen E., LaMonte, Bernadette H., Harmison, George G., Puls, Imke, Fischbeck, Kenneth H., Holzbaur, Erika L.F.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2006
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063705/
https://ncbi.nlm.nih.gov/pubmed/16505168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200511068
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