A motor neuron disease–associated mutation in p150(Glued) perturbs dynactin function and induces protein aggregation

The microtubule motor cytoplasmic dynein and its activator dynactin drive vesicular transport and mitotic spindle organization. Dynactin is ubiquitously expressed in eukaryotes, but a G59S mutation in the p150(Glued) subunit of dynactin results in the specific degeneration of motor neurons. This mut...

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Detalhes bibliográficos
Main Authors: Levy, Jennifer R., Sumner, Charlotte J., Caviston, Juliane P., Tokito, Mariko K., Ranganathan, Srikanth, Ligon, Lee A., Wallace, Karen E., LaMonte, Bernadette H., Harmison, George G., Puls, Imke, Fischbeck, Kenneth H., Holzbaur, Erika L.F.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2006
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063705/
https://ncbi.nlm.nih.gov/pubmed/16505168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200511068
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