Comparison of the cytotoxic activity of melphalan with L-prolyl-m-L-sarcolysyl-L-p-fluorophenylalanine in human tumour cell lines and primary cultures of tumour cells from patients.

m-L-sarcolysin (m-L-SL) is an isomer of melphalan (Mel) with the di(2-chloroethyl) amino group being substituted in the meta position of phenylalanine. By covalent conjugation of amino acids to m-L-SL, a peptide complex consisting of six m-L-SL-based oligopeptides known as peptichemio (PTC) was deve...

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Bibliographic Details
Main Authors: Larsson, R., Dhar, S., Ehrsson, H., Nygren, P., Lewensohn, R.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group|1 1998
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063025/
https://ncbi.nlm.nih.gov/pubmed/9703278
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