Vaccine effect using a live attenuated nef-deficient simian immunodeficiency virus of African green monkeys in the absence of detectable vaccine virus replication in vivo

Immunization of adult macaques with live attenuated simian immunodeficiency viruses (SIVs) lacking the nef genes has been shown to protect against challenge with full-length pathogenic SIV. To test live attenuated virus vaccines for the first time in a natural host we have constructed a mutant SIV f...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Beer, Brigitte, Baier, Michael, zur Megede, Jan, Norley, Stephen, Kurth, Reinhard
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1997
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20568/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9108105/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.8.4062
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