Arsenic-induced PML targeting onto nuclear bodies: Implications for the treatment of acute promyelocytic leukemia

Acute promyelocytic leukemia (APL) is associated with the t(15;17) translocation, which generates a PML/RARα fusion protein between PML, a growth suppressor localized on nuclear matrix-associated bodies, and RARα, a nuclear receptor for retinoic acid (RA). PML/RARα was proposed to block myeloid diff...

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Detalhes bibliográficos
Main Authors: Zhu, Jun, Koken, Marcel H. M., Quignon, Frédérique, Chelbi-Alix, Mounira K., Degos, Laurent, Wang, Zhen Yi, Chen, Zhu, de Thé, Hugues
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC20553/
https://ncbi.nlm.nih.gov/pubmed/9108090
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