Correlation of germ-line mutations and two-hit inactivation of the WT1 gene with Wilms tumors of stromal–predominant histology

The WT1 gene, located on chromosome 11p13, is mutated in a low number of Wilms tumors (WTs). Germ-line mutations in the WT1 gene are found in patients with bilateral WT and/or associated genital tract malformations (GU). We have identified 19 hemizygous WT1 gene mutations/deletions in 64 patient sam...

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Hauptverfasser: Schumacher, V., Schneider, S., Figge, A., Wildhardt, G., Harms, D., Schmidt, D., Weirich, A., Ludwig, R., Royer-Pokora, B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences of the USA 1997
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC20552/
https://ncbi.nlm.nih.gov/pubmed/9108089
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