Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease

Huntington disease (HD) is associated with abnormal expansions of a CAG repeat close to the 5′ end of the IT15 gene. We have assembled a set of 293 HD subjects whose ages of onset were known and sized their HD CAG repeats. These repeats accounted for 69% of the variance of age of onset when we used...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Rubinsztein, David C., Leggo, Jayne, Chiano, Mathias, Dodge, Alan, Norbury, Gail, Rosser, Elisabeth, Craufurd, David
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20534/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9108071/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.8.3872
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!