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Calcium-sensitive regulation of monoamine oxidase-A contributes to the production of peroxyradicals in hippocampal cultures: implications for Alzheimer disease-related pathology

BACKGROUND: Calcium (Ca(2+)) has recently been shown to selectively increase the activity of monoamine oxidase-A (MAO-A), a mitochondria-bound enzyme that generates peroxyradicals as a natural by-product of the deamination of neurotransmitters such as serotonin. It has also been suggested that incre...

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Main Authors: Cao, Xia, Wei, Zelan, Gabriel, Geraldine G, Li, XinMin, Mousseau, Darrell D
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central|1 2007
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2048967/
https://ncbi.nlm.nih.gov/pubmed/17868476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-8-73
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