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Sir2 deacetylates histone H3 lysine 56 to regulate telomeric heterochromatin structure in yeast
At telomeric heterochromatin in yeast the Sir protein complex spreads from Rap1 sites to silence adjacent genes. This cascade is believed to occur when Sir2, an NAD(+)-dependent enzyme deacetylates histone H3 and H4 N termini, in particular histone H4 K16, enabling more Sir protein binding. Lysine 5...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2048486/ https://ncbi.nlm.nih.gov/pubmed/17889663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.07.021 |
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