Nucleotide sequences and heterologous expression of tcmG and tcmP, biosynthetic genes for tetracenomycin C in Streptomyces glaucescens.

Míreanna Comhchosúla

• The tcmVI region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens encodes the tetracenomycin F1 monooxygenase, tetracenomycin F2 cyclase, and, most likely, a second cyclase.
  le: Summers, R G, et al.
  Foilsithe: (1993)
• Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase.
  le: Summers, R G, et al.
  Foilsithe: (1992)
• Transcriptional analysis of the Streptomyces glaucescens tetracenomycin C biosynthesis gene cluster.
  le: Decker, H, et al.
  Foilsithe: (1993)
• Isolation of tetracenomycin C-nonproducing Streptomyces glaucescens mutants.
  le: Motamedi, H, et al.
  Foilsithe: (1986)
• Cloning and heterologous expression of a gene cluster for the biosynthesis of tetracenomycin C, the anthracycline antitumor antibiotic of Streptomyces glaucescens.
  le: Motamedi, H, et al.
  Foilsithe: (1987)