Amino Acid Substitutions in the S2 Region Enhance Severe Acute Respiratory Syndrome Coronavirus Infectivity in Rat Angiotensin-Converting Enzyme 2-Expressing Cells

To clarify the molecular basis of severe acute respiratory syndrome coronavirus (SARS-CoV) adaptation to different host species, we serially passaged SARS-CoV in rat angiotensin-converting enzyme 2 (ACE2)-expressing cells. After 15 passages, the virus (Rat-P15) came to replicate effectively in rat A...

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Detalhes bibliográficos
Main Authors: Fukushi, Shuetsu, Mizutani, Tetsuya, Sakai, Kouji, Saijo, Masayuki, Taguchi, Fumihiro, Yokoyama, Masaru, Kurane, Ichiro, Morikawa, Shigeru
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045470/
https://ncbi.nlm.nih.gov/pubmed/17652383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01143-07
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