The ORF49 Protein of Murine Gammaherpesvirus 68 Cooperates with RTA in Regulating Virus Replication

Our functional mapping study of murine gammaherpesvirus 68 (MHV-68, or γHV-68) revealed that a mutant harboring a transposon at the ORF49 locus (ORF49(null)) evidenced a highly attenuated in vitro growth. ORF49 resides adjacent to and in an opposite direction from RTA, the primary switch of the gamm...

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Main Authors: Lee, Sangmi, Cho, Hye-Jeong, Park, Jung-Jin, Kim, Yong-Sun, Hwang, Seungmin, Sun, Ren, Song, Moon Jung
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2007
Teme:
Genome Replication and Regulation of Viral Gene Expression
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045426/
https://ncbi.nlm.nih.gov/pubmed/17634244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00001-07
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