Mutations in the LHX3 gene cause dysregulation of pituitary and neural target genes that reflect patient phenotypes

The LHX3 LIM-homeodomain transcription factor is required for correct development of the mammalian pituitary gland and spinal motoneurons. Mutations in the LHX3 gene underlie complex diseases featuring combined anterior pituitary hormone deficiency and, in specific cases, loss of neck rotation consi...

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Autori principali: Savage, Jesse J., Hunter, Chad S., Clark-Sturm, Surilda L., Jacob, Tanya M., Pfaeffle, Roland W., Rhodes, Simon J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045125/
https://ncbi.nlm.nih.gov/pubmed/17616267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2007.05.017
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