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The effects of pH on the affinity of pirenzepine for muscarinic receptors in the guinea-pig ileum and rat fundus strip.
1 Dose-ratios obtained with pirenzepine on the guinea-pig ileum at 30 degrees C are indistinguishable from those obtained at 37 degrees C. 2. In 0.1 M NaCl at 37 degrees C the pKa of pirenzepine for the loss of its last ionizable proton is 8.2. The ionization of pirenzepine is therefore markedly aff...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
1982
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2044615/ https://ncbi.nlm.nih.gov/pubmed/6897199 |
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