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The effects of pH on the affinity of pirenzepine for muscarinic receptors in the guinea-pig ileum and rat fundus strip.

1 Dose-ratios obtained with pirenzepine on the guinea-pig ileum at 30 degrees C are indistinguishable from those obtained at 37 degrees C. 2. In 0.1 M NaCl at 37 degrees C the pKa of pirenzepine for the loss of its last ionizable proton is 8.2. The ionization of pirenzepine is therefore markedly aff...

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Bibliografiske detaljer
Main Authors: Barlow, R. B., Chan, M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1982
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2044615/
https://ncbi.nlm.nih.gov/pubmed/6897199
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