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Depletion of Alveolar Macrophages Decreases the Dissemination of a Glucosylceramide-Deficient Mutant of Cryptococcus neoformans in Immunodeficient Mice

In previous studies we showed that a Cryptococcus neoformans mutant lacking glucosylceramide (Δgcs1) is avirulent and unable to reach the brain when it is administered intranasally into an immunocompetent mouse and is contained in a lung granuloma. To determine whether granuloma formation is key for...

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Autors principals: Kechichian, Talar B., Shea, John, Del Poeta, Maurizio
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2044542/
https://ncbi.nlm.nih.gov/pubmed/17664261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00587-07
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