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The Bacterial Second Messenger cdiGMP Exhibits Promising Activity as a Mucosal Adjuvant

The development of mucosal adjuvants is still a critical need in vaccinology. In the present work, we show that bis(3′,5′)-cyclic dimeric GMP (cdiGMP), a second messenger that modulates cell surface properties of several microorganisms, exerts potent activity as a mucosal adjuvant. BALB/c mice were...

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Hlavní autoři: Ebensen, Thomas, Schulze, Kai, Riese, Peggy, Morr, Michael, Guzmán, Carlos A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2044480/
https://ncbi.nlm.nih.gov/pubmed/17567766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00119-07
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