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Inhibition of thromboxane A2 biosynthesis in human platelets by burimamide.

1 Burimamide selectively inhibited the formation of thromboxane A2 from prostaglandin endoperoxides by human platelet microsomes in a dose-dependent manner (IC50 = 2.5 x 10(-5) M). Burimamide was found to be equipotent to imidazole as a thromboxane synthetase inhibitor. 2 Metiamide, cimetidine and a...

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Main Authors: Allan, G., Eakins, K. E., Kulkarni, P. S., Levi, R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 1980
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2044402/
https://ncbi.nlm.nih.gov/pubmed/6781572
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