Phenobarbitone interaction with oral contraceptive steroids in the rabbit and rat.

1 The effect of phenobarbitone on the single dose pharmacokinetics of the synthetic steroids, ethinyloestradiol (EE2) and norethisterone, has been studied in the rabbit and rat. 2 EE2 is subject to an extensive first pass effect (96%). The plasma clearance of EE2 approaches total hepatic blood flow....

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Main Authors: Back, D. J., Breckenridge, A. M., Crawford, F. E., Orme, M. L., Rowe, P. H.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1980
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2044275/
https://ncbi.nlm.nih.gov/pubmed/7397454
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