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Transgenic Overexpression of ADAM12 Suppresses Muscle Regeneration and Aggravates Dystrophy in Aged mdx Mice

Muscular dystrophies are characterized by insufficient restoration and gradual replacement of the skeletal muscle by fat and connective tissue. ADAM12 has previously been shown to alleviate the pathology of young dystrophin-deficient mdx mice, a model for Duchenne muscular dystrophy. The observed ef...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jørgensen, Louise Helskov, Jensen, Charlotte Harken, Wewer, Ulla M., Schrøder, Henrik Daa
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043520/
https://ncbi.nlm.nih.gov/pubmed/17982130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.070435
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