Effects of chronic nitric oxide synthase inhibition on the cardiovascular responses to cannabinoids in vivo and in vitro

BACKGROUND AND PURPOSE: Since the vasorelaxant potency of the endocannabinoid anandamide is enhanced in perfused mesenteric vascular beds from rats made hypertensive by chronic inhibition of NO synthase (L-NAME in drinking water), we hypothesized that in vivo, anandamide-induced vasodilatation would...

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Bibliographic Details
Main Authors: Wheal, A J, Bennett, T, Randall, M D, Gardiner, S M
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2007
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043496/
https://ncbi.nlm.nih.gov/pubmed/17245361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707136
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