Azithromycin Blocks Quorum Sensing and Alginate Polymer Formation and Increases the Sensitivity to Serum and Stationary-Growth-Phase Killing of Pseudomonas aeruginosa and Attenuates Chronic P. aeruginosa Lung Infection in Cftr(−)(/)(−) Mice

The consequences of O-acetylated alginate-producing Pseudomonas aeruginosa biofilms in the lungs of chronically infected cystic fibrosis (CF) patients are tolerance to both antibiotic treatments and effects on the innate and the adaptive defense mechanisms. In clinical trials, azithromycin (AZM) has...

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Main Authors: Hoffmann, Nadine, Lee, Baoleri, Hentzer, Morten, Rasmussen, Thomas Bovbjerg, Song, Zhijun, Johansen, Helle Krogh, Givskov, Michael, Høiby, Niels
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2007
Teme:
Mechanisms of Action: Physiological Effects
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043275/
https://ncbi.nlm.nih.gov/pubmed/17620382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01011-06
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