Optimization of the Dosage of Flucytosine in Combination with Amphotericin B for Disseminated Candidiasis: a Pharmacodynamic Rationale for Reduced Dosing

Amphotericin B and flucytosine (5FC) have an additive effect when used for disseminated candidiasis. Here, we bridge the results of an experimental pharmacodynamic study to humans and demonstrate that a 5FC dosage of 25 mg/kg of body weight/day in four divided doses in combination with amphotericin...

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Detalhes bibliográficos
Main Authors: Hope, William W., Warn, Peter A., Sharp, Andrew, Reed, Paul, Keevil, Brian, Louie, Arnold, Walsh, Thomas J., Denning, David W., Drusano, George L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043255/
https://ncbi.nlm.nih.gov/pubmed/17682101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00488-07
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