Histatin-Derived Monomeric and Dimeric Synthetic Peptides Show Strong Bactericidal Activity towards Multidrug-Resistant Staphylococcus aureus In Vivo

Homodimerization of histatin-derived peptides generally led to improved bactericidal activity against Staphylococcus aureus in vitro. In vivo, monomers and dimers were equally active in killing bacteria in mice with a soft tissue infection. Altogether, these peptides are promising compounds for the...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Welling, Mick M., Brouwer, Carlo P. J. M., van ′t Hof, Wim, Veerman, Enno C. I., Amerongen, Arie V. Nieuw
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2007
Gaiak:
Mechanisms of Action: Physiological Effects
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043174/
https://ncbi.nlm.nih.gov/pubmed/17620386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00196-07
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