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Population analysis of the non linear red blood cell partitioning and the concentration-effect relationship of draflazine following various infusion rates

Aims To investigate the impact of the specific red blood cell binding on the pharmacokinetics and pharmacodynamics of the nucleoside transport inhibitor draflazine after i.v. administration at various infusion rates. It was also aimed to relate the red blood cell (RBC) occupancy of draflazine to the...

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Detalhes bibliográficos
Main Authors: Snoeck, E., Piotrovskij, V., Jacqmin, P., Van Peer, A., Danhof, M., Ver Donck, K., Woestenborghs, R., Van Belle, H., Van Bortel, L., Van Gool, R., Dupont, A. G., Heykants, J.
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley-Blackwell 1997
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042791/
https://ncbi.nlm.nih.gov/pubmed/9205820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1997.00593.x
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