Diazepam–omeprazole inhibition interaction: an in vitro investigation using human liver microsomes

1. The metabolism of diazepam to its primary metabolites 3-hydroxydiazepam (3HDZ) and nordiazepam (NDZ) was evaluated in human liver microsomes. The 3HDZ pathway was the major route of metabolism representing 90% of total metabolism with a V(max) /K(m)ratio of 0.50–7.26 μl min(−1) mg (−1) protein. 2...

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Bibliographic Details
Main Authors: ZOMORODI, K, HOUSTON, J B
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 1996
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042665/
https://ncbi.nlm.nih.gov/pubmed/8864312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1996.03563.x
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