Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death

Nerve growth factor (NGF) binds to TrkA receptor and triggers activation of numerous signaling cascades, which play critical roles in neuronal plasticity, survival, and neurite outgrowth. To mimic NGF functions pharmacologically, we developed a high-throughput screening assay to identify small-molec...

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Bibliographic Details
Main Authors: Jang, Sung-Wuk, Okada, Masashi, Sayeed, Iqbal, Xiao, Ge, Stein, Donald, Jin, Peng, Ye, Keqiang
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042206/
https://ncbi.nlm.nih.gov/pubmed/17911251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706662104
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