Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death

Nerve growth factor (NGF) binds to TrkA receptor and triggers activation of numerous signaling cascades, which play critical roles in neuronal plasticity, survival, and neurite outgrowth. To mimic NGF functions pharmacologically, we developed a high-throughput screening assay to identify small-molec...

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Hlavní autoři: Jang, Sung-Wuk, Okada, Masashi, Sayeed, Iqbal, Xiao, Ge, Stein, Donald, Jin, Peng, Ye, Keqiang
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042206/
https://ncbi.nlm.nih.gov/pubmed/17911251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706662104
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