Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance

Side-population (SP) cells within cancers and cell lines are rare cell populations known to enrich cancer stem-like cells. In this study, we characterized SP cells from the human breast cancer cell line MCF7 as a model for cancer stem-like cells. Compared with non-SP cells, MCF7 SP cells had higher...

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Bibliographische Detailangaben
Hauptverfasser: Zhou, Jiangbing, Wulfkuhle, Julia, Zhang, Hao, Gu, Peihua, Yang, Yanqin, Deng, Jianghong, Margolick, Joseph B., Liotta, Lance A., Petricoin, Emanuel, Zhang, Ying
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042178/
https://ncbi.nlm.nih.gov/pubmed/17911267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702596104
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