Effect of prednisolone on the growth of human bone marrow cells in vitro.

The addition of prednisolone to autostimulatory cultures of human bone marrow in agar results in the formation of an increased number of granulocytic aggregates. The effect is dependent on the concentration of cultured cells and does not occur at low cell concentration. The increase in aggregate num...

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Main Authors: Stevenson, R. D., Lucie, N. P., Gray, A. C.
Formato: Artigo
Idioma:Inglês
Publicado em: 1978
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2041392/
https://ncbi.nlm.nih.gov/pubmed/309764
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spelling pubmed-20413922011-11-29 Effect of prednisolone on the growth of human bone marrow cells in vitro. Stevenson, R. D. Lucie, N. P. Gray, A. C. Br J Exp Pathol Research Article The addition of prednisolone to autostimulatory cultures of human bone marrow in agar results in the formation of an increased number of granulocytic aggregates. The effect is dependent on the concentration of cultured cells and does not occur at low cell concentration. The increase in aggregate numbers is maximal early in the culture and occurs at steroid concentrations which are comparable with pharmacological levels. Prednisolone directly inhibits the responsiveness of granulocytic precursors to colony-stimulating activity (CSA) and it is suggested that the stimulatory effect is indirect and may be caused by a steroid action on mediator production. These findings may be relevant to the polymorphonuclear leucocytosis induced by glucocorticoids. 1978-10 /pmc/articles/PMC2041392/ /pubmed/309764 Text en
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Research Article
spellingShingle Research Article
Stevenson, R. D.
Lucie, N. P.
Gray, A. C.
Effect of prednisolone on the growth of human bone marrow cells in vitro.
description The addition of prednisolone to autostimulatory cultures of human bone marrow in agar results in the formation of an increased number of granulocytic aggregates. The effect is dependent on the concentration of cultured cells and does not occur at low cell concentration. The increase in aggregate numbers is maximal early in the culture and occurs at steroid concentrations which are comparable with pharmacological levels. Prednisolone directly inhibits the responsiveness of granulocytic precursors to colony-stimulating activity (CSA) and it is suggested that the stimulatory effect is indirect and may be caused by a steroid action on mediator production. These findings may be relevant to the polymorphonuclear leucocytosis induced by glucocorticoids.
author Stevenson, R. D.
Lucie, N. P.
Gray, A. C.
author_facet Stevenson, R. D.
Lucie, N. P.
Gray, A. C.
author_sort Stevenson, R. D.
title Effect of prednisolone on the growth of human bone marrow cells in vitro.
title_short Effect of prednisolone on the growth of human bone marrow cells in vitro.
title_full Effect of prednisolone on the growth of human bone marrow cells in vitro.
title_fullStr Effect of prednisolone on the growth of human bone marrow cells in vitro.
title_full_unstemmed Effect of prednisolone on the growth of human bone marrow cells in vitro.
title_sort effect of prednisolone on the growth of human bone marrow cells in vitro.
publishDate 1978
url https://ncbi.nlm.nih.gov/pmc/articles/PMC2041392/
https://ncbi.nlm.nih.gov/pubmed/309764
_version_ 1748870466479587328

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