Inhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleus

Bilateral, high-frequency stimulation (HFS) of the subthalamic nucleus (STN) is the surgical therapy of choice for movement disability in advanced Parkinson's disease (PD), but this procedure evokes debilitating psychiatric effects, including depressed mood, of unknown neural origin. Here, we r...

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Detalhes bibliográficos
Main Authors: Temel, Yasin, Boothman, Laura J., Blokland, Arjan, Magill, Peter J., Steinbusch, Harry W. M., Visser-Vandewalle, Veerle, Sharp, Trevor
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040465/
https://ncbi.nlm.nih.gov/pubmed/17942692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704144104
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