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Assessment of conformational ensemble sizes necessary for specific resolutions of coverage of conformational space

The size of conformational ensembles required for regular coverage of the conformational space of drug-like molecules was examined. Using the conformer generation program Omega, the number of regularly-distributed conformers (NRC) of flexible compounds was determined as a function of the root mean s...

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Библиографические подробности
Главные авторы: Borodina, Yulia V., Bolton, Evan, Fontaine, Fabien, Bryant, Stephen H.
Формат: Artigo
Язык:Inglês
Опубликовано: 2007
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040338/
https://ncbi.nlm.nih.gov/pubmed/17569521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci7000956
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