PTGER1 and PTGER2 receptors mediate regulation of progesterone synthesis and type 1 11β-hydroxysteroid dehydrogenase activity by prostaglandin E(2) in human granulosa–lutein cells

In luteinizing granulosa cells, prostaglandin E(2) (PGE(2)) can exert luteotrophic actions, apparently via the cAMP signalling pathway. In addition to stimulating progesterone synthesis, PGE(2) can also stimulate oxidation of the physiological glucocorticoid, cortisol, to its inactive metabolite, co...

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Autores principales: Chandras, C, Harris, T E, López Bernal, A, Abayasekara, D R E, Michael, A E
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Endocrinology 2007
Materias:
Regular Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040272/
https://ncbi.nlm.nih.gov/pubmed/17761898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/JOE-07-0128
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