PI3 kinase blockade by Ad-PTEN inhibits invasion and induces apoptosis in RGP and metastatic melanoma cells.

BACKGROUND: Melanoma is an aggressive tumor with a propensity to rapidly metastasize. The PTEN gene encodes a phosphatase with an unusual dual specificity for proteins and lipids. Mutations of PTEN have been found in various human cancers, including glioblastoma, prostate, breast, lung, and melanoma...

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Main Authors: Stewart, Alexis L., Mhashilkar, Abner M., Yang, Xiaohong Helena, Ekmekcioglu, Suhendan, Saito, Yuji, Sieger, Kerry, Schrock, Robert, Onishi, Eric, Swanson, Xin, Mumm, John B., Zumstein, Lou, Watson, Graham J., Snary, David, Roth, Jack A., Grimm, Elizabeth A., Ramesh, Rajagopal, Chada, Sunil
Formato: Artigo
Idioma:Inglês
Publicado: 2002
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040008/
https://ncbi.nlm.nih.gov/pubmed/12435856
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