A novel natural product compound enhances cAMP-regulated chloride conductance of cells expressing CFTR[delta]F508.

BACKGROUND: Cystic fibrosis (CF) results from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a chloride channel localized at the plasma membrane of diverse epithelia. The most common mutation leading to CF, Delta F508, occurs in the first nucleotide-b...

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Bibliographic Details
Main Authors: deCarvalho, Ana C. V., Ndi, Chi P., Tsopmo, Apollinaire, Tane, Pierre, Ayafor, Johnson, Connolly, Joseph D., Teem, John L.
Format: Artigo
Language:Inglês
Published: 2002
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2039976/
https://ncbi.nlm.nih.gov/pubmed/12080183
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