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Stat1 Acetylation Inhibits Inducible Nitric Oxide Synthase Expression in Interferon-γ Treated RAW264.7 Murine Macrophages
BACKGROUND: We hypothesized that acetylation of the Stat1 regulates interferon-γ (IFN-γ) mediated macrophage expression of inducible nitric oxide synthase (iNOS). METHODS: RAW 264.7 iNOS expression was induced with IFN-γ. Deacetylase inhibitors trichostatin A (TSA) or valproic acid (VPA) were added....
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2034510/ https://ncbi.nlm.nih.gov/pubmed/17689680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2007.02.016 |
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