Preclinical studies with the anti-CD19-saporin immunotoxin BU12-SAPORIN for the treatment of human-B-cell tumours.

The immunotoxin BU12-SAPORIN was constructed by covalently coupling the single-chain ribosome-inactivating protein saporin to the anti-CD19 monoclonal antibody BU12 via a disulphide linker using the heterobifunctional reagent SPDP. The immunoreactivity and specificity of BU12-SAPORIN was identical t...

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Detalhes bibliográficos
Main Authors: Flavell, D. J., Flavell, S. U., Boehm, D. A., Emery, L., Noss, A., Ling, N. R., Richardson, P. R., Hardie, D., Wright, D. H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034088/
https://ncbi.nlm.nih.gov/pubmed/8519647
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