Normal colonic mucosa in hereditary non-polyposis colorectal cancer shows no generalised increase in somatic mutation.

Hereditary non-polyposis colorectal cancer (HNPCC) has recently been linked to germline defects of DNA repair genes. Colorectal tumours in HNPCC frequently show DNA microsatellite instability, but it is not certain whether this mutator phenotype occurs throughout the morphologically normal colonic m...

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Autores principales: Williams, G. T., Geraghty, J. M., Campbell, F., Appleton, M. A., Williams, E. D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2033807/
https://ncbi.nlm.nih.gov/pubmed/7734304
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