Normal colonic mucosa in hereditary non-polyposis colorectal cancer shows no generalised increase in somatic mutation.

Hereditary non-polyposis colorectal cancer (HNPCC) has recently been linked to germline defects of DNA repair genes. Colorectal tumours in HNPCC frequently show DNA microsatellite instability, but it is not certain whether this mutator phenotype occurs throughout the morphologically normal colonic m...

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Bibliografiset tiedot
Päätekijät: Williams, G. T., Geraghty, J. M., Campbell, F., Appleton, M. A., Williams, E. D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 1995
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2033807/
https://ncbi.nlm.nih.gov/pubmed/7734304
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