Rapid up-regulation of mdr1 expression by anthracyclines in a classical multidrug-resistant cell line.

Studies were carried out in a variant human multidrug-resistant (MDR) cell line CEM/A7R, which expresses very low levels of mdr1 mRNA and P-glycoprotein (P-gp). The induction of mdr1 RNA expression by three anthracyclines, (doxorubicin, daunorubicin, epirubicin), VP-16 and two vinca alkaloids (vincr...

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Autores principales: Hu, X. F., Slater, A., Wall, D. M., Kantharidis, P., Parkin, J. D., Cowman, A., Zalcberg, J. R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2033794/
https://ncbi.nlm.nih.gov/pubmed/7734315
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