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Colorectal carcinomas show frequent allelic loss on the long arm of chromosome 17 with evidence for a specific target region.

Allelic loss is a common mechanism of inactivation of tumour-suppressor genes in colorectal carcinomas. A number of known or putative tumour-suppressor genes including NF1, BRCA1, NME1, NME2 and prohibitin are present on the long arm of chromosome 17, and this region has not been extensively analyse...

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Main Authors: Leggett, B., Young, J., Buttenshaw, R., Thomas, L., Young, B., Chenevix-Trench, G., Searle, J., Ward, M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1995
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2033787/
https://ncbi.nlm.nih.gov/pubmed/7734302
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