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Novel Toxicity of the Unedited GluR2 AMPA Receptor Subunit Dependent on Surface Trafficking and Increased Ca(2+)-Permeability
RNA editing modifies the GluR2 AMPA receptor subunit pore loop at the Q/R site and limits receptor Ca(2+) permeability. Editing failure is implicated in neurodegenerative diseases, including amyotrophic lateral sclerosis. We show that channels with unedited GluR2 are highly toxic in cultured hippoca...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2031227/ https://ncbi.nlm.nih.gov/pubmed/17544687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2007.04.006 |
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