Essential role of the tyrosine kinase substrate phospholipase C-γ1 in mammalian growth and development

The activation of many tyrosine kinases leads to the phosphorylation and activation of phospholipase C-γ1 (PLC-γ1). To examine the biological function of this protein, homologous recombination has been used to selectively disrupt the Plcg1 gene in mice. Homozygous disruption of Plcg1 results in embr...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Ji, Qun-sheng, Winnier, Glenn E., Niswender, Kevin D., Horstman, Debra, Wisdom, Ron, Magnuson, Mark A., Carpenter, Graham
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1997
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20311/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9096335/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.7.2999
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