19F nuclear magnetic resonance analysis of 5-fluorouracil metabolism in wild-type and 5-fluorouracil-resistant Nectria haematococca.

A mutant (furA3) was isolated from the S1 wild-type strain of Nectria haematococca on the basis of its resistance to 5-fluorouracil (5FU). This mutant has greatly reduced activity of uracil phosphoribosyltransferase, a pyrimidine salvage enzyme catalyzing the synthesis of UMP from uracil. The metabo...

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Detalhes bibliográficos

Publicado no:	Appl Environ Microbiol
Principais autores:	Parisot, D, Malet-Martino, M C, Crasnier, P, Martino, R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1989
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC203107/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2604390/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aem.55.10.2474-2479.1989
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