Local DNA stretching mimics the distortion caused by the TATA box-binding protein
X-ray structures of the TATA box-binding protein complexed with its DNA target show that the nucleic acid is severely bent away from the protein and also strongly unwound. We have used molecular mechanics and energy mapping to understand how such an unusual conformation can be induced. The results s...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1997
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20310/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9096334/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.7.2993 |
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