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Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway

Malignant fibrous histiocytoma (MFH), now termed high-grade undifferentiated pleomorphic sarcoma, is a commonly diagnosed mesenchymal tumor, yet both the underlying molecular mechanisms of tumorigenesis and cell of origin remain unidentified. We present evidence demonstrating that human mesenchymal...

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Hlavní autoři: Matushansky, Igor, Hernando, Eva, Socci, Nicholas D., Mills, Joslyn E., Matos, Tulio A., Edgar, Mark A., Singer, Samuel, Maki, Robert G., Cordon-Cardo, Carlos
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2030456/
https://ncbi.nlm.nih.gov/pubmed/17948129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31377
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