Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients

Patients with scleroderma receiving Iloprost as a treatment for severe Raynaud’s phenomenon report a reduction in skin tightness, suggesting that this drug inhibits skin fibrosis. Connective tissue growth factor (CTGF), a recently described profibrotic cytokine, acts downstream and in concert with T...

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Main Authors: Stratton, Richard, Shiwen, Xu, Martini, Giorgia, Holmes, Alan, Leask, Andrew, Haberberger, Thomas, Martin, George R., Black, Carol M., Abraham, David
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2001
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC203022/
https://ncbi.nlm.nih.gov/pubmed/11457877
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