Mechanism of platelet inhibition by nitric oxide: In vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinase

Nitric oxide (NO) is a potent vasodilator and inhibitor of platelet activation. NO stimulates production of cGMP and activates cGMP-dependent protein kinase (G kinase), which by an unknown mechanism leads to inhibition of Gα(q)-phospholipase C-inositol 1,4,5-triphosphate signaling and intracellular...

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Publikašuvnnas:	Proc Natl Acad Sci U S A
Váldodahkkit:	Wang, Guang-Rong, Zhu, Yan, Halushka, Perry V., Lincoln, Thomas M., Mendelsohn, Michael E.
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	National Academy of Sciences 1998
Fáttát:	Biological Sciences
Liŋkkat:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20183/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9560198/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.9.4888
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