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Apparent autoinduction of valproate β-oxidation in humans

AIMS: The study aimed to show whether autoinduction of valproate (VPA) along its β-oxidation pathway occurred upon chronic dosing in humans. METHODS: Twelve young volunteers without active illness took sodium valproate (NaVPA) 200 mg orally 12 hourly for 3 weeks. On days 7 and 21, serial blood sampl...

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Detalhes bibliográficos
Main Authors: McLaughlin, Daniel B, Andrews, Jaymie A, Hooper, Wayne D, Cannell, Graeme R, Eadie, Mervyn J, Dickinson, Ronald G
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014955/
https://ncbi.nlm.nih.gov/pubmed/10792197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00191.x
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