Dramatic inhibition of amiodarone metabolism induced by grapefruit juice

AIMS: Grapefruit juice increases blood concentrations of many drugs metabolized by CYP3A. Amiodarone is metabolized by CYP3A to N-desethylamiodarone (N-DEA). The aim of this study was to determine amiodarone kinetics when administrated with and without grapefruit juice. METHODS: Eleven healthy adult...

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Detalhes bibliográficos
Main Authors: Libersa, Christian C, Brique, Serge A, Motte, Kokou B, Caron, Jacques F, Guédon-Moreau, Laurence M, Humbert, Luc, Vincent, A, Devos, Patrick, Lhermitte, Michel A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2000
Assuntos:
Short Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014943/
https://ncbi.nlm.nih.gov/pubmed/10759694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00163.x
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