Pharmacokinetic and pharmacodynamic characterization of OROS® and immediate-release amitriptyline

AIMS: To characterize the pharmacokinetics of amitriptyline and its metabolite nortriptyline following OROS® and IR treatments, and to correlate them with anticholinergic side-effects. METHODS: The pharmacokinetics and safety of amitriptyline following administration of an osmotic controlled release...

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Bibliographic Details
Main Authors: Gupta, Suneel K, Shah, Jaymin C, Hwang, Stephen S
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 1999
Subjects:
Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014871/
https://ncbi.nlm.nih.gov/pubmed/10383563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00973.x
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